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. 2019 Jun 11;14(6):e0216463. doi: 10.1371/journal.pone.0216463

Fig 4. mRNA expression of known epigenetically modified genes in response to weeklong intraperitoneal injections with BIX-01294.

Fig 4

Out of the six genes examined, the 0.5 mg/kg dose was able to significantly upregulate mRNA levels of IL-6, Gad67 and Nanog. The 1 mg/kg dose was effective at inducing mRNA levels of Nanog, Reln and Bdnf9a. Klf4 mRNA levels were unchanged. Results determined by ANOVA and Tukey post hoc analysis. *p<0.05; **p<0.01; ***p<0.001.