. Author manuscript; available in PMC: 2019 Jun 11.

Published in final edited form as: J Biomol Screen. 2016 Jan 8;21(4):381–390. doi: 10.1177/1087057115624637

Table 2.

Confirmed Hits Inhibit ADP/ATP Exchange Mediated by Human Adenine Nucleotide Translocase (ANT) Expressed in Isolated Yeast Mitochondria and Lactococcus lactis.

	Yeast Mitochondria			L. lactis
	hANT1	hANT2	hANT3	hANT4	hANT1	hANT2	hANT3
IC₅₀ (μM)
Closantel	52 ± 15	92 ± 32	100 ± 32	64 ± 25	15 ± 2.8	24 ± 4.2	47 ± 11
CD437	10 ± 1.5	18 ± 6.4	9.5 ± 2.7	22 ± 12	54 ± 9	36 ± 6.3	94 ± 19
Leelamine	87 ± 25	>100	98 ± 25	95 ± 42	>100	>100	47 ± 11
cATR	0.077 ± 0.041	0.41 ± 12	0.42 ± 0.12	0.77 ± 0.47	0.0024 ± 0.0005	0.0017 ± 0.0004	0.0023 ± 0.0007

Carboxyatractyloside (cATR) was used as a positive control. IC₅₀ values are means ± SEM of at least three independent experiments.