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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Biochemistry. 2017 Jul 20;56(30):3934–3944. doi: 10.1021/acs.biochem.7b00476

Figure 1. Toxoflavin biosynthesis and toxoflavin-like gene cluster in B. thailandensis E264.

Figure 1.

(A) Diagrams of the toxoflavin biosynthetic gene cluster found in B. glumae BGRl (top) and related cluster identified in B. thailandensis E264 (bottom). The numbers in the B. thailandensis cluster refer to the last two digits of the locus tag (BTH_II12XX) assigned during genomic sequencing (e.g., 83=BTH_II1283). Homologues in the two clusters are depicted with identically colored arrows and assigned the gene name used for B. glumae BGRl. Colors denote predicted or experimentally verified gene functions: red, efflux or resistance; green, regulation; blue, biosynthesis; grey, transposition; orange and pink, unknown function. (B) Proposed biosynthetic pathway of toxoflavin in B. glumae BGRl and unknown molecule in B. thailandensis E264. The atom numbering scheme used in the manuscript can be seen illustrated on 6-DMT (4).