Table 2.

Univariate Model of Clinical Factors and Risk of Breast Cancer Recurrence

	Patients (N = 2,327)
Factor	No.	%	HR	95% CI	P
Tumor size, cm					< .01
≤ 2	1,603	68.9	1.00
> 2	667	28.7	2.15	1.72 to 2.68
Missing	57	2.4
Lymph node status					< .01
Negative	1,558	66.9	1.00
Positive	765	32.9	2.01	1.62 to 2.50
Missing	4	0.2
ER/PR status					< .01
ER positive/PR positive	1,099	47.2	1.00
ER positive/PR negative or	424	18.2	1.06	0.77 to 1.47
ER negative/PR positive
ER negative/PR negative	436	18.8	2.02	1.55 to 2.63
Missing	368	15.8
Nuclear grade					< .01
Modified Black’s grade 1	281	12.1	1.0
Modified Black’s grade 2	1,223	52.6	0.93	0.64 to 1.34
Modified Black’s grade 3	685	29.4	1.50	1.03 to 2.18
Missing	138	5.9
Surgery					< .01
Modified mastectomy	1,367	58.8	1.00
Segmental mastectomy	952	40.9	0.59	0.47 to 0.75
Missing	8	0.3
Chemotherapy					< .01
No chemotherapy	1,263	54.3	1.00
Anthracycline	643	27.6	1.64	1.29 to 2.08
Anthracycline and taxane	335	14.4	1.08	0.77 to 1.52
Other	52	2.2	1.54	0.78 to 3.01
Missing	34	1.5
Endocrine treatment					< .01
Yes	1,005	43.2	1.00
No	1,305	56.1	1.91	1.51 to 2.42
Missing	17	0.7
Radiation					.15
Yes	1,017	43.7	1.00
No	1,295	55.6	1.18	0.94 to 1.47
Missing	15	0.7

Abbreviations: HR, hazard ratio; ER, estrogen receptor; PR, progesterone receptor.