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Ins2Akita mice show significant progression of diabetes by 6 months, including (A) elevated fasting blood glucose levels (P < 0.0001, Student's t-test) and (B) lower body weight (P < 0.005, Students t-test) relative to WT littermates. (C) Ins2Akita suffered significantly greater mortality than WT mice starting sharply at 6 months (logrank test, P = 0.008).
