Figure 4.

COMP-Ang1 treatment inhibits proliferative deep vascular remodeling in aged Ins2^Akita retinas. (A) Representative ×40 confocal Z-stack images of WT and Ins2^Akita deep plexus. (B–E) Several indices of vascularity: (B) vessel length, (C) lacunarity, (D) number of vessel junctions, and (E) vascular area indicate that between 6 and 10 months of age, the deep vascular plexus of Ins2^Akita retinas is remodeled to increase vascular density relative to age-matched WT retinas (black bars and asterisks). In contrast, AAV2.COMP-Ang1–treated retinas were statistically more similar to WT retinas for all comparisons (red bars and asterisks). N = 5 (WT, NI, and PBS), N = 8 (Reporter), N = 9 (CA1) *P < 0.05, **P < 0.01, ***P < 0.005.