Figure 6.

Retinal thinning was not prevented or improved after delayed COMP-Ang1 treatment. (A) Considerable retinal thinning occurred between baseline (6 months) and the experimental endpoint (10.5 months) in WT and Ins2^Akita mice. However, retinal thickness of Ins2^Akita mice was below that of age-matched WT littermates at all radial distances from the optic nerve head. (B) Representative images of HRA (left) and OCT images of all four study groups at the 10.5-month endpoint. The dashed blue line is at approximately 0.5 radial distance from the optic nerve head (solid green line). (C) Average retinal thickness at increasing radial distances from the optic nerve head is represented by a colored line for each group. Note that central retinas of the two AAV2-treated groups are considerably thicker than that of the PBS-injected group, whereas peripheral retinas of all Ins2^Akita groups are similar. (D) Same retinal thickness data (and color code) as in (C) but represented as bar graphs with pairwise comparisons performed at each radial distance that showed a significant difference among the group means. AAV2.COMP-Ang1 (AAV2.CA1) treatment did not prevent significant peripheral retinal thinning (*P < 0.05; **P < 0.01).