Figure 7.

RGC and visual acuity loss. (A) RGC counts in retinal flat mounts immunolabeled with Brn3, compared across groups at the 10.5-month endpoint. RGC counts of AAV2.REPORTER treated Ins2^Akita retinas were significantly lower than all other groups. (B) Averaged OD+OS OptoMotry scores of 10.5-month-old WT and Ins2Akita mice. All Ins2^Akita mice showed significant loss of visual acuity compared to age-matched WT littermates at 10.5 months. *P < 0.05, **P < 0.01, and ***P < 0.001, respectively.