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. 2019 Jun 6;14:4145–4155. doi: 10.2147/IJN.S202466

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© 2019 Pei et al.

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Fullerol suppresses cell fusion and formation of multinuclear cells in RAW264.7 macrophage cell line.

Notes: Cells were stained with the FITC-conjugated phalloidin, a peptide with high ability of binding to the microfilament component F-actin. (A) Images were taken under a fluorescent microscope; (B) numbers of the multinuclear cells in a randomly selected area consisting of 50 nuclei in cell cultures with different treatments. Cell fusion which led to the formation of multinuclear was induced by LPS, and the induction effect of LPS was inhibited with the addition of fullerol. LPS: LPS (100 ng/mL) treatment; LPS + FUL: treatment of LPS (100 ng/mL) combined with fullerol (1 µM).

Abbreviations: FUL, fullerol; NT, no treatment; LPS, lipopolysaccharide.