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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Biochemistry. 2019 Jan 31;58(8):1094–1108. doi: 10.1021/acs.biochem.8b01027

Figure 9.

Figure 9.

(A) 2D NOESY imino region lacking NOEs that would indicate wobble base pairs. (B) NOEs indicating that U8 is in can flip out from the helix. (C) Predicted structure of GUCU duplex. (D) Secondary structure model for GUCU duplex. All red U’s may not be flipped out at the same time. Middle GC pairs may not always be present. (E) & (F) Model duplexes (GUCC and GUC) created to compare chemical shifts of the internal loop residues with those of the GUCU duplex.