Table 1.

Newly reported HIF inhibitors

Inhibitor	Mechanism of Inhibition
Benzopyranyl triazole (1)	Increased HIF-1α hydroxylation
BIX01294 (2)	Increased HIF-1α hydroxylation/HIF-1α protein degradation
Cardenolides (3)	Decreased HIF-1 transcriptional activity
CRLX-101 (4)	Decreased HIF-1α protein accumulation
EZN-2208 (5)	Decreased HIF-1α protein expression and transcriptional activity
Glyceollins (6)	Decreased HIF-1α translation/stability
IDF-1174 (7)	Increased HIF-1α degradation
LBH589 (8)	Increased HIF-1α degradation
MPT0G157 (9)	Increased HIF-1α degradation
Vorinostat (10)	Decreased HIF-1/2α translation/nuclear localization/stability
NNC 55–0396 (11)	Decreased HIF-1α protein expression/translation/Increased HIF-1α hydroxylation
Kresoxim-methyl analogues (12)	Decreased HIF-1α stability
PT2385 (13) and PT2399 (14)	Decreased HIF-2 heterodimerization