Table 1:

Comparative results of trabecular bone area (Tb. B.Ar/T.Ar, %) and adiposity (%) within the tissue area (T.Ar) of male and female distal rat femurs treated with Scl-Ab (3 mg/kg and 50 mg/kg) and hPTH (75 μg/kg/d) relative to the vehicle-treated groups (Treatment group/Vehicle) after 4 and 26 weeks of treatment. Data for Tb. B.Ar/T.Ar (%) and T.Ar adiposity (%) shown as mean ± S.E.M. *p<0.05 vs. Vehicle. Abbreviations: Tb. B.Ar= trabecular bone area, in mm². Ma.Ar = marrow area, in mm². T.Ar= tissue area [calculated as trabecular bone area + marrow area (Tb. B.Ar+Ma.Ar)], in mm². All measurements and ROIs exclude cortical bone.

		Week 4				Week 26
		Tb. B.Ar/T. Ar (%)	Tb. B.Ar/T. Ar Relative to Vehicle	T.Ar Adiposity (%)	T.Ar Adiposity Relative to Vehicle	Tb. B.Ar/T. Ar (%)	Tb. B.Ar/T. Ar Relative to Vehicle	T.Ar Adiposity (%)	T.Ar Adiposity Relative to Vehicle
Males	Vehicle	21.485	1.000	1.308	1.000	23.531	1.000	2.906	1.000
	Scl-Ab 3 mg/kg	28.456	1.324	1.025	0.784	38.523*	1.637	1.797*	0.618
	Scl-Ab 50 mg/kg	25.922	1.206	1.066	0.815	55.245*	2.348	1.357*	0.467
	hPTH	43.386*	2.019	0.936	0.716	63.542*	2.700	0.796*	0.274
Females	Vehicle	34.475	1.000	0.613	1.000	38.825	1.000	1.203	1.000
	Scl-Ab 3 mg/kg	38.515	1.117	1.123*	1.834	49.664*	1.279	1.087	0.903
	Scl-Ab 50 mg/kg	43.152*	1.252	1.288*	2.102	72.555*	1.869	0.545*	0.453
	hPTH	43.649*	1.266	0.685	1.118	57.766*	1.488	0.555*	0.461