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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Science. 2018 Aug 24;361(6404):800–803. doi: 10.1126/science.aat6777

Fig. 3.

Fig. 3

Model extensions. Model fit to data for CV-A6 and E18 using the best-fitting model extensions: (A) a five-fold increase in pathogenicity from around 2010 for CV-A6, (B) a change in antigenicity and (C) a 9% increase in transmissibility from around 2006 for E18. Dashed vertical lines indicate the estimated time when the changes occurred. See details in Fig. 2. Parameter values in Table S4.