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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Ann Biomed Eng. 2019 Apr 8;47(7):1596–1610. doi: 10.1007/s10439-019-02263-8

Figure 7.

Figure 7.

Doxorubicin contractile depression is exacerbated by 100U/mL TNF-α. (A) Effects of 1nM doxorubicin and TNF-α on twitch force are additive. (B) Effects of 1nM doxorubicin and TNF-α on twitch force are significantly more than additive, thus synergistic. (C) Effects of 10nM doxorubicin and TNF-α on twitch force are additive. (B) Effects of 10nM doxorubicin and TNF-α on twitch force are significantly more than additive, thus synergistic. Data are expressed as mean±SEM of 4 donors with 4 biological replicates.