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. 2019 Mar 6;31:5–13. doi: 10.1016/j.ddtec.2019.02.002

Fig. 1.

Fig. 1

A schematic view of the mechanism of action of bifunctional molecules that induce targeted protein degradation. (A) PROteolysis TArgeting Chimeric (PROTAC) molecules consisting of a target affinity group (red), flexible linker (blue) and E3 ligase binding group (black) exemplified for the CUL4CRBN E3 ligase; (B) adamantyl-tagged (black) bifunctional molecules that bind to HSP70; (C) (Boc)3-arginine-tagged (black) bifunctional molecules that bind to the 20S proteasome. (For interpretation of the references to colour in the text, the reader is referred to the web version of this article.)