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. 2019 Jun 11;9:8480. doi: 10.1038/s41598-019-44854-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map clustering representation for most significantly differentially expressed NLR-associated genes in glioma. We have grouped all the glioma samples by glioma grade 2, 3 and 4. Here, G2, G3 and G4 represents grade 2, grade 3, and grade 4 respectively. (A) Shows gene expression of most differentially expressed genes, MSR1, NLRC4, NLRP12, NOD2, CASP1 and PYCARD across the grade 2 (orange) & grade 3 (green) of LGG samples. Similarly, panel (B,C) shows characteristic gene expression clusters between grade 4 (orange) & grade 2 (green) and grade 4 (orange) & grade 3 (green) glioma samples respectively. The segregation of grade 4 glioma from the grade 2 and grade 3 glioma is evident as the resulting heatmaps form expression ‘blocks’. Here, relative up-regulated and down-regulated gene expression, are shown in red and blue respectively.