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. 2019 Jun 11;10:2548. doi: 10.1038/s41467-019-10461-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — VMR analysis in DeepSEA annotated SNPs in PREDO I dataset. a Percentage of models (G, E, GxE or G + E) with the lowest AIC explaining variable DNA methylation using the PREDO I dataset with DeepSEA annotated SNPs. b Distribution of the locations of all VMRs and tagVMRs with best model E, G, G + E and GxE on the 450k array using only DeepSEA variants in relationship to CpG-Islands based on the Illumina 450 K annotation. c Distribution of gene-centric locations of all VMRs and tagVMRs with best model E, G, G + E and GxE on the 450k array using only DeepSEA variants