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. 2019 Jun 11;10:2548. doi: 10.1038/s41467-019-10461-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Functional annotation of VMR-mapping in DeepSEA annotated SNPs in PREDO I dataset. a Histone mark enrichment for all VMRs. The Y-axis denotes the fold enrichment/depletion as compared to no-VMRs. Blue bars indicate significant enrichment/depletion, grey bars non-significant differences based on Fisher-tests. b Histone mark enrichment for tagVMRs with best model E, G, G + E and GxE relative to all VMRs. Green colour indicates depletion, red colour indicates enrichment. Thick black lines around the rectangles indicate significant enrichment/depletion based on Fisher-tests. c Histone mark enrichment for all DeepSEA variants in the dataset. Blue bars indicate significant enrichment/depletion based on Fisher-tests. d Histone mark enrichment for all DeepSEA variants involved in models where either G, G + E or GxE is the best model as compared to all tested DeepSEA variants. Green colour indicates depletion, red colour indicates enrichment. Thick black lines around the rectangles indicate significant enrichment/depletion based on Fisher-tests