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. 2019 Jun 11;10:2548. doi: 10.1038/s41467-019-10461-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Enrichment of DeepSEA variants for GWAS associations. a Enrichment for nominal significant GWAS associations for all tested DeepSEA variants and their LD proxies for GWAS for ADHD (attention-deficit hyperactivity disorder), ASD (autism spectrum disorder), BMI (body mass index), BP (bipolar disorder), CrossDisorder, IBD (inflammatory bowel disease), MDD (major depressive disorder), SCZ (schizophrenia) and T2D (Type 2 diabetes). The Y-axis denotes the fold enrichment with regard to non-DeepSEAvariants. Blue bars indicate significant enrichment/depletion based on Fisher-tests. b Enrichment for nominal significant GWAS hits for DeepSEA variants and their LD proxies involved in best models with G, G + E or GxE as compared to all tested DeepSEA variants. Green colour indicates depletion, red colour indicates enrichment. Thick black lines around the rectangles indicate significant enrichment/depletion based on Fisher-tests