Table 1.
Overview of investigated cohorts
| Cohort | PREDO I | PREDO II | DCHS I | DCHS II | UCI | MoBa |
|---|---|---|---|---|---|---|
| Sample size | 817 | 146 | 107 | 151 | 121 | 1023 |
| Methylation array | Illumina 450 K | Illumina EPIC | Illumina 450 K | Illumina EPIC | Illumina EPIC | Illumina 450 K |
| Methylation data processing | Funnorm and Combat | Funnorm and Combat | SWAN and Combat | BMIQ and Combat | Funnorm and Combat | BMIQ and Combat |
| SNP genotyping | Illumina Human Omni Express Exome | Illumina Human Omni Express Exome | Illumina PsychArray | Illumina GSA | Illumina Human Omni Express | Illumina HumanExome Core |
| Infant gender male | 433 (53.0%) | 75 (51.4%) | 63 (58.8%) | 83 (55.0%) | 65 (53.7%) | 478 (46.7%) |
| Maternal age mean (sd) | 33.28 (5.79) | 32.25 (4.92) | 26.27 (5.87) | 27.42 (5.93) | 28.47 (4.91) | 29.92 (4.32) |
| Partity mean (sd) | 1.05 (1.02) | 0.87 (1.03) | 0.98 (1.12) | 1.09 (1.07) | 1.11 (1.15) | 0.83 (0.88) |
| Caesarian section | 169 (20.7%) | 36 (24.7%) | 19 (17.6%) | 35 (23.2%) | 37 (30.6%) | 228 (22.3%) |
| Pre-pregnancy BMI mean (sd) | 27.42 (6.40) | 25.37 (5.79) | Not available | Not available | 27.90 (6.44) | 24.05 (4.19) |
| Maternal smoking yes | Exclusion criterion | Exclusion criterion | 7.40 (10.52)a | 4.94 (9.43)a | 10 (8.2%) | 148 (14.4%) |
| Gestational diabetes yes | 183 (22.4%) | 19 (13.0%) | No cases available | No cases available | 9 (7.4%) | 15 (1.5%) |
| Hypertension yes | 275 (33.7%) | 31 (21.2%) | 2 (0.19%) | 2 (1.3%) | 7 (5.8%) | 50 (4.9%) |
| Betamethasone treatment yes | 35 (4.3%) | 2 (1.5%) | Not available | Not available | No cases available | Not available |
| Anxiety score mean (sd) | 33.93 (7.90)b | 34.43 (8.38)b | 5.70 (4.15)c | 5.32 (3.91)c | 1.67 (0.41)d | 4.79 (1.36)e |
| Depression score mean (sd) | 11.34 (6.47)f | 11.53 (6.98)f | 17.64 (12.10)g | 12.52 (11.55)g | 0.68 (0.41)h | 5.24 (1.57)e |
a Based on ASSIST Tobacco Score
b STAI sum scores
c SRQ-20
d STAI average scores
e Based on Hopkins Symptom Checklist
f CESD sum scores
g BDI-II
h CESD average score