Table 1.
Summary of differentially expressed lncRNA targets and mRNAs involved in hair follicle and skin development.
| Hair follicle development, morphogenesis, and hair cycle process | lncRNA targets | DKK1 KRT25 HOXC13 FOXE1 SOS1 DSG4 LHX2 CDH3 MYSM1 ERCC2 CD109 FZD3 ALX4 LGR5 RELA CELSR1 WNT10A LDB1 LRP4 FGF10 FST |
| mRNA | DKK1 KRT25 HOXC13 FOXN1 LGR4 ACVR1B SOX9 SOSTDC1 DSG4 TP63 LAMA5 NOTCH1 TGFB2 LHX2 INHBA ZDHHC21 DNASE1L2 KRT71 LHX2 TMEM79 FZD3 FZD6 ALX4 LGR5 KRT71 TNF-alpha CELSR1 MSX2 EGFR KRT17 WNT10A KRT27 FOXN1 SMO APCDD1 LRP4 SNAI1 FGF10 | |
| Epidermis development and morphogenesis | lncRNA targets | WNT16 DKK1 KRT25 DSG4 SOS1 FOXE1 HOXC13 OVOL1 |
| mRNA | FOXN1 INHBA TGFB2 LRP4 NOTCH1 KDF1 WNT10A LAMA5 DKK1 EDAR CELSR1 LGR5 TP63 ALX4 KRT25 DLL1 SOSTDC1 SOX9 DSG4 LHX2 ACVR1B LGR4 VDR TMEM79 ALOX15B SFN MSX2 CYP27B1 H2AFY2 FOXE1 KRT36 MAFF KRT84 HES5 DNASE1L2 KRT27 CST6 HOXC13 | |
| Skin development and morphogenesis | lncRNA targets | WNT16 CLDN1 COL5A1 DKK1 DHCR24 KRT25 ALOXE3 DSG4 COL5A2 SOS1 PSEN1 JUP OVOL1 FOXE1 HOXC13 |
| mRNA | FOXN1 TGFB2 INHBA KDF1 WNT16 COL1A1 ALOX12B TFAP2B EDAR CLDN1 VDR LAMA5 COL5A1 DLL1 LGR5 DKK1 DHCR24 GRHL2 KRT25 ALX4 SOX9 SOSTDC1 FA2H PTCH2 ACVR1B LHX2 ASPRV1 CSTA ALOXE3 COL1A2 ITGA3 CYP26B1 LRP4 NOTCH1 WNT10A TGM3 ACER1 CELSR1 ITGB4 ABCA12 TP63 ATP8A2 WNT5A LGR4 KRT1 FRAS1 TCF15 KRT27 DSG4 COL5A2 JUP FOXE1 DNASE1L2 SFN HOXC13 KRT71 | |
| Cell differentiation, death, and migration | lncRNA targets | SFRP1 PPP1R16B CDH5 IL1B ENG ALMS1 PSMB8 SFRP2 WNT5B DKKL1 TRAF6 PSEN1 TMEM176A IRF4 LHX8 FGB PM20D1 WNT16 PAX8 PTTG1IP NLE1 AURKB DPEP1 CIB1 TAF9B TEX11 FGG CDK1 PDK4 TDGF1 IDO1 MAEL CLEC5A HSP90B1 RBM10 PTK2B IGF1 AIFM2 |
| mRNA | NOTCH1 MYCN SFRP1 WNT5B DLL1 WNT16 HES5 PDZD7 MFSD2A ITGA8 TRIM62 TH FOXB1 TGFB2 LGI1 DPEP1 MYRF PLA2G3 PTCH2 LAMA5 FZD1 EDN1 TDGF1 NOTCH1 CLEC5A LTBP3 TGM3 PRDM1 CTGF UNC5C KLF5 GRIP1 ISG15 BMPER BMP2 TNR PTK2B TFAP2 PTCH1 | |
| WNT signaling pathway | lncRNA targets | WNT16 SFRP1 FZD4 SFRP2 DKK1 FBXW11 PSEN1 HOXC13 CSNK1A1 DAAM1 |
| mRNA | WIF1 WNT16 SFRP1 MMP7 WNT10A FZD1 SFRP4 WNT3 WNT5A SFRP5 SERPINF1 CAMK2A BAMBI FZD4 FZD5 CSNK1E SFRP2 NOTUM PLCB4 WNT2 WNT2B FZD3 VANGL1 DKK1 NFATC4 DAAM2 FZD6 PRICKLE1 WNT8B PPARD HOXC13 PRKACB FRAT2 FOSL1 DAAM1 | |
| TNF signaling pathway | lncRNA targets | IL1B IL18R1 DNM1L JUNB |
| mRNA | PIK3R5 CREB3L4 SELE MAP2K6 EDN1 NOD2 ICAM-1 PIK3CB IL15 FOS CXCL10 PIK3R3 JUNB MLKL MAP3K5 MMP14 MMP9 MMP3 TNF-alpha | |
| MAPK signaling pathway | lncRNA targets | IL1B MAPKAPK5 TRAF6 NTRK2 PDGFRA PLA2G4D SOS1 |
| mRNA | IL1R1 MAP2K6 DUSP4 IL1A TGFB2 CACNA2D3 PLA2G4F CACNA1D FGF19 CACNB1 GADD45B FOS BDNF DUSP2 PDGFRA HSPA1B RASGRP2 IL1R2 PTPRR DUSP1 CACNG6 MAP3K6 HSPA2 MAPKAPK3 HSPA6 MAP3K5 PLA2G4D PLA2G4E MRAS FLNC FGF9 TGFB3 MEF2C FGFR4 | |
| Hedgehog signaling pathway | lncRNA targets | FBXW11 CSNK1A1 CDON |
| mRNA | HHIP GLI1 GLI2 CSNK1E LRP2 CDON GPR161 ARRB1 SMO PRKACB CUL3 |
Genes marked in bold indicate the potential lncRNA targets that overlapped with mRNAs in the important hair follicle developmental stages.