Table 4.

Characteristics of brain connectivity studies

Reference	Population	Study population		MMSE		Anosognosia measurement instrument	Neuro image technique	Findings
		Interest	HC	Interest	HC
Ries et al., 2012	AD/MCI	5 AD	12	25* [17–30]	30* [29–30]	Memory Awareness Rating Scale	Self-appraisal task fMRI	Attenuated functional connectivity between mPFC and proximal areas, bilateral dorsolateral prefrontal cortex, bilateral caudate and left posterior hippocampus.
		7 MCI		25* [17–30]
Berlingeri et al., 2015	AD with vs without anosognosia	10 with anosognosia	15	24.5 (2.92)	28.87 (1.25)	AQ-D	rsfMRI	Reduced functional connectivity within DMN, within network comprised of the lateral temporal cortex, the hippocampus and the insula, and reduced connectivity between hippocampus and insular cortex.
		8 without anosognosia
Perrotin et al., 2015	AD	23	30	21.52 (4.62) [12–29]	29.17 (0.83) [28–30]	Self-Rating Scale of Memory Function	rsfMRI/ FDG-PET	Hypometabolism in orbitofrontal (OFC) and posterior cingulate (PCC) cortices; reduced intrinsic connectivity between OFC and medial temporal lobe (MTL) and PCC and MTL.
Vannini et al., 2017	aMCI	31	251	27.1 (1.9)	28.9 (1.1)	Memory Functioning Questionnaire	rsfMRI/ FDG-PET	Hypometabolism in precuneus and hippocampus. Reduced functional connectivity between precuneus and bilateral inferior parietal lobes (IPL), left PCC, left OFC. Reduced functional connectivity between right hippocampus and left MTL and right fusiform gyrus.

AD Alzheimer’s disease, AQ-D Anosognosia Questionnaire Dementia, DMN default mode network, FDG-PET 18F-fluorodeoxyglucose positron emission tomography, fMRI functional magnetic resonance imaging, HC healthy controls, MCI mild cognitive impairment, MMSE Mini-mental state examination; rs-fMRI resting state fMRI

*Median and range