Table 3.
Results of the binary logistic regression analysis of variables tested for associations with LGA
| Variable | All (n = 186) | LGA (n = 98) | No LGA (n = 88) | Crude data | Adjusted data | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | ||||
| Trimester 1 (n = 155) | |||||||
| HbA1c, mmol/mol | 52.4 ± 10.5 | 54.1 ± 1.0 | 50.4 ± 9.5 | 1.04 (1.00, 1.07) | 0.03 | 1.04 (1.00, 1.08) | 0.02* |
| HbA1c, % | 6.9 ± 1.0 | 7.1 ± 1.0 | 6.8 ± 0.9 | ||||
| Mean glucose, mmol/l | 7.8 ± 1.4 | 7.9 ± 1.3 | 7.7 ± 1.5 | 1.12 (0.88, 1.41) | 0.35 | 1.16 (0.91, 1.49) | 0.24 |
| SD, mmol/l | 3.2 ± 0.9 | 3.2 ± 0.8 | 3.2 ± 0.9 | 1.07 (0.74, 1.55) | 0.71 | 1.09 (0.73, 1.62) | 0.67 |
| CV% | 40.5 ± 7.2 | 40.5 ± 7.2 | 40.6 ± 7.3 | 1.00 (0.95, 1.04) | 0.90 | 0.99 (0.95, 1.04) | 0.77 |
| Time in target, %a | 50.0 ± 14.1 | 48.2 ± 13.6 | 51.9 ± 14.5 | 0.98 (0.96, 1.00) | 0.10 | 0.98 (0.95, 1.00) | 0.07 |
| Time above target, % | 43.0 ± 15.5 | 44.8 ± 14.6 | 40.9 ± 16.3 | 1.02 (0.99, 1.04) | 0.11 | 1.02 (1.00, 1.04) | 0.07 |
| Time below target, % | 7.0 ± 5.0 | 7.0 ± 5.1 | 7.2 ± 5.0 | 0.99 (0.93, 1.06) | 0.81 | 0.98 (0.92, 1.05) | 0.60 |
| MAGE | 7.7 ± 2.0 | 7.8 ± 1.8 | 7.5 ± 2.1 | 1.08 (0.92, 1.27) | 0.37 | 1.09 (0.92, 1.30) | 0.33 |
| HBGI | 5.5 ± 3.7 | 5.6 ± 3.4 | 5.3 ± 4.1 | 1.02 (0.94, 1.11) | 0.60 | 1.04 (0.94, 1.13) | 0.46 |
| LBGI | 2.6 ± 1.6 | 2.6 ± 1.6 | 2.7 ± 1.6 | 0.97 (0.79, 1.18) | 0.74 | 0.94 (0.76, 1.16) | 0.54 |
| Trimester 2 (n = 165) | |||||||
| HbA1c, mmol/mol | 45.2 ± 7.9 | 46.4 ± 7.4 | 43.7 ± 8.3 | 1.05 (1.00–1.09) | 0.03 | 1.05 (1.01–1.10) | 0.02* |
| HbA1c, % | 6.3 ± 0.7 | 6.4 ± 0.7 | 6.1 ± 0.8) | ||||
| Mean glucose, mmol/l | 7.4 ± 1.2 | 7.6 ± 1.0 | 7.1 ± 1.3 | 1.48 (1.10, 1.98) | <0.01 | 1.53 (1.12, 2.08) | <0.001* |
| SD, mmol/l | 2.8 ± 0.7 | 2.9 ± 0.6 | 2.7 ± 0.7 | 1.58 (0.98, 2.56) | 0.06 | 1.65 (1.00, 2.74) | <0.05* |
| CV% | 37.7 ± 6.3 | 37.8 ± 5.9 | 37.7 ± 6.7 | 1.00 (0.95, 1.05) | 0.92 | 1.00 (0.95, 1.06) | 0.93 |
| Time in target, %a | 54.7 ± 13.7 | 51.8 ± 12.3 | 57.9 ± 14.4 | 0.96 (0.94, 0.99) | <0.01 | 0.96 (0.94, 0.99) | <0.01* |
| Time above target, % | 38.1 ± 14.9 | 41.9 ± 12.8 | 34.0 ± 15.9 | 1.04 (1.02, 1.06) | <0.001 | 1.04 (1.02, 1.07) | <0.001* |
| Time below target, % | 7.2 ± 5.1 | 6.4 ± 4.5 | 8.0 ± 5.7 | 0.94 (0.88, 0.99) | 0.04 | 0.93 (0.87, 0.99) | 0.02* |
| MAGE | 6.8 ± 1.5 | 7.0 ± 1.4 | 6.6 ± 1.6 | 1.21 (0.98, 1.48) | 0.07 | 1.22 (0.98, 1.52) | 0.06 |
| HBGI | 4.0 ± 2.9 | 4.4 ± 2.4 | 3.6 ± 3.3 | 1.11 (0.98, 1.24) | 0.08 | 1.12 (0.99, 1.26) | 0.07 |
| LBGI | 2.7 ± 1.6 | 2.4 ± 1.4 | 3.0 ± 1.8 | 0.80 (0.66, 0.97) | 0.02 | 0.77 (0.62, 0.94) | 0.01* |
| Trimester 3 (n = 167) | |||||||
| HbA1c, mmol/mol | 45.7 ± 7.6 | 47.2 ± 6.7 | 44.0 ± 8.2 | 1.06 (1.02, 1.11) | <0.01 | 1.06 (1.02, 1.11) | <0.01* |
| HbA1c, % | 6.3 ± 0.7 | 6.5 ± 0.6 | 6.2 ± 0.8 | ||||
| Mean glucose, mmol/l | 7.1 ± 1.1 | 7.3 ± 1.1 | 6.8 ± 1.1 | 1.57 (1.13, 2.16) | <0.01 | 1.57 (1.12, 2.19) | <0.001* |
| SD, mmol/l | 2.6 ± 0.6 | 2.6 ± 0.6 | 2.5 ± 0.6 | 1.58 (0.93, 2.68) | 0.08 | 1.60 (0.92, 2.77) | 0.09 |
| CV% | 36.0 ± 5.8 | 35.9 ± 5.5 | 36.1 ± 6.2 | 0.99 (0.94, 1.05) | 0.83 | 0.99 (0.94, 1.05) | 0.84 |
| Time in target, %a | 59.8 ± 13.3 | 57.6 ± 12.8 | 62.2 ± 13.4 | 0.97 (0.95, 1.00) | 0.02 | 0.97 (0.95, 1.00) | 0.04* |
| Time above target, % | 33.7 ± 14.8 | 37.0 ± 13.5 | 30.2 ± 15.3 | 1.03 (1.01, 1.06) | <0.01 | 1.03 (1.01, 1.06) | <0.01* |
| Time below target, % | 6.5 ± 5.6 | 5.4 ± 4.4 | 7.6 ± 6.4 | 0.93 (0.87, 0.98) | <0.01 | 0.92 (0.86, 0.98) | <0.01* |
| MAGE | 6.2 ± 1.4 | 6.3 ± 1.4 | 6.0 ± 1.5 | 1.16 (0.93, 1.44) | 0.18 | 1.16 (0.92, 1.45) | 0.20 |
| HBGI | 3.3 ± 2.5 | 3.6 ± 2.7 | 2.9 ± 2.3 | 1.15 (1.00, 1.34) | 0.04 | 1.15 (1.00, 1.34) | 0.05 |
| LBGI | 2.6 ± 1.7 | 2.3 ± 1.4 | 2.9 ± 1.9 | 0.78 (0.63, 0.94) | <0.01 | 0.76 (0.61, 0.94) | <0.01* |
Results are given as mean ± SD
aDefined as glucose level 3.5–7.8 mmol/l
*A significant association (p<0.05) in a hierarchal binary logistic regression analysis with adjustment for age, smoking, BMI and CGM device