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. 2019 Jun 11;9:8454. doi: 10.1038/s41598-019-44936-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of ketamine on ITC from temporal cortex recording. (A) The time-frequency plots of ITC at 1^st recording (0–30 min) after saline (top) and ketamine (bottom) administration. (B) The time-frequency plots of ITC at 2^nd recording (70–100 min) after saline (top) and ketamine (bottom) administration. In time-frequency plots, warmer color (reds, yellows) indicate higher ITC. (C) The ITC (10–80 Hz) at 1^st recording after saline (circle line) and ketamine (square line) administration. (D) The ITC (10–80 Hz) at 2^nd recording after saline (circle line) and ketamine (square line) administration. Data represent mean ± SEM (n = 16). *p < 0.05, **p < 0.01, significant differences between the groups; two-way repeated measures ANOVA followed by Bonferroni multiple comparison test.