Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 11;9:8481. doi: 10.1038/s41598-019-44834-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Angiotensinogen (Agt) alters endoplasmic reticulum (ER) stress & inflammation: Relative gene expression of ER stress markers normalized to Gapdh measured in epididymal fat pad of low fat fed male wild-type (Wt) and Agt transgenic (Tg) mice (A). The expression of Activating transcription factor 4 (Atf4), binding immunoglobulin protein (Bip), and C/EBP homologous protein (Chop) were significantly (p < 0.05) higher in Agt-Tg mice compared to control group (Wt) (A). Higher levels of inflammatory markers interleukin-6 (Il-6) and monocyte chemoattractant protein 1 (Mcp-1) were also observed in Agt-Tg mice compared to Wt (B,C). No changes were observed in ER stress markers in low fat fed Agt knockout mice (KO) (D), however, when KO mice were fed high fat die,t ER stress markers such as Chop and Bip (but not Atf4) showed significantly reduced expression compared to Wt group (E). Data is presented as mean ± SEM. (n = 6–8 each group). *p < 0.05.