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. 2019 Jun 11;9:8481. doi: 10.1038/s41598-019-44834-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Levels of microRNAs in adipocytes treated with angiotensin II (Ang II) and the receptor inhibitors: Ang II treated 3T3-L1 adipocytes had significantly (p < 0.05) reduced expression of miR-30 family compared to control (A,B). Whereas Ang II treated 3T3-L1 adipocytes had induced expression of miR-708-5p and miR-143-3p compared to control groups (C,D). Telmisartan reversed the effects of Ang II by upregulating miR-30 family or downregulating miR-708-5p and miR-143-3p in vitro (A,B). C: Control, A: Ang II, A + T: Ang II + AT1 blocker Telmisartan, A + P-186: Ang II + AT2 blocker, A + T + P-186: Ang II + AT1 blocker Telmisartan + AT2 blocker. Common letters indicate no significance. Data is presented as mean ± SEM (n = 6–8). p < 0.05.