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. 2019 Jun 11;9:8460. doi: 10.1038/s41598-019-44906-9

Figure 2.

Figure 2

Murine model of subarachnoid haemorrhage. (A,B) Time courses of CPP and ICP changes after induction of SAH or sham surgery. Note that ICP increases minutes after SAH induction but returns to near baseline after 3 h, leading to a similar CPP as that before induction. (*p < 0.05; error bars indicate SEM; group sizes: SAH-neutropenia/cerebral perfusion group 2, n = 7; SAH-control/cerebral perfusion group 4, n = 6; sham-neutropenia/cerebral perfusion group 1, n = 4; sham-control/cerebral perfusion group 3, n = 5). (C) Representative images of cerebral cortical perfusion before and after induction of SAH in mice receiving vehicle or anti-Ly6G antibody to induce neutropenia. (D) Panels 1, 2, and 3 show representative images 15 min, 3 h, and 24 h after induction of SAH.