Table 2.
Genes with fixed non-synonymous changes on the human lineage, genes under positive selection with HHMCs, and deleterious candidate HHMCs.
| Fixed HHMCs | ADAM18, ADSL, AHR, ANKMY1, ANKRD30A, BBIP1, BOD1L1, C1orf159, C3, CASC5, CDH16, DCHS1, DNHD1, DNMT3L, FRMD8, GBP5, GLDC, GREB1L, GRM6, KIF26B, LMNB2, NCOA6, NOTO, OTUD5, PRDM10, PROM2, RFNG, SCAP, SHROOM4, SIX5, SPAG5, SSH2, TBC1D3, ZNF106, ZNF185, ZNHIT2 |
| Selection 2014 | C11orf80, CKAP5, GREB1L, HMCN1, NLRX1, PDZD3, PRDM2, RB1CC1 |
| Selection 2015 | MSS51, NCOA6, OMD, SPAG17, SPAG5 |
| Selection 2016 | ACE, ADSL, ALMS1, ANKRD30A, BZRAP1, DNAH1, GREB1L, KMT2C, NWD1, PROM2, RASA1, STAB1, STARD9, ZNF106 |
| Selection 2017 | ADSL, AKAP8, BAP1, BBIP1, BCAR3, CAPN5, CR2, CSMD2, DNAH1, ENTHD1, FAAH, FRMD8, GBP5, GBP7, GPR157, GTF3C5, HERC5, HERC6, HMCN1, HRASLS5, KATNA1, KIF15, KIF18A, LYST, MKL1, MYH3, NAALADL1, NCOA6, PRDM10, PRDM2, PROM2, PTPRC, RNF44, SCAP, SLC12A8, SLC25A45, SLITRK1, TIGD3, TMEM235, TRGV4, TTC6, VOPP1, ZNF501, ZNF502, ZNHIT2 |
| Grantham | ABHD14A-ACY1, ACY1, ABHD14A, CCDC158, CCDC30, DNHD1, EML2, ERI1, GBA3, GREB1, OR1K1, TTC6, UBQLN3, UIMC1, ZBP1, ZNF510, ZNHIT2 |
| SIFT | BEND2, CCT6B, COPA, CUL4B, GBP7, KRTAP10-10, MEPE, NHEJ1, OR1K1, SLC6A15, TPO, ZNF510 |
| PolyPhen-2 | FSHR, NLN, TPO |
| CADD | C11orf80, C5orf66, CCT6B, CDH15, CEP128, CPM, FGF21, FMN2, FUT1, H2AFY, HERC6, KCNK5, KPNA4, KRT33A, KRT8P12, MUM1, NR1H2, OPRM1, PDSS2, ROCK1, RPS15P9, SLC22A31, SUCLG2P4, TMPRSS7, UNC5D |
| GWAVA | ANK2, COPA, CTRC, CYP2B6, MAPK10, MCTP1, SLC38A6, SYT1, YTHDC1 |