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. 2019 Jun 11;9:8511. doi: 10.1038/s41598-019-44838-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DBTA probe adhesion to signet ring cell colon carcinoma (SRCC) tissue is force-dependent. (a) Position profile of a P-selectin DBTA probe rolling on a tissue section (SRCC 48 y/o case) at 0.75 dyne/cm². Video frame rate = 175 fps (Supplementary Video S8). (b) Velocity profile of the P-selectin DBTA probe tracked in (a). (c) Increasing levels of applied force initially increased then decreased the lifetime of P-selectin DBTA probe adhesion to SRCC tissue. Data shown are mean adhesion duration in seconds ± SD of 30 separate pauses at each wall shear stress collected in a 100 μm × 100 μm region. ^$F = 12.59 > F_{0.01, 6,273} = 2.80 (d) Increasing levels of applied force initially decreased then increased the off-rate (k_off) of P-selectin DBTA probe from the SRCC tissue. Data shown represent the estimation of P-selectin DBTA probe k_off using the method of maximum likelihood⁴⁸ from 30 separate pauses at each wall shear stress. Error bars represent 95% CI. ^#Levene’s test = 4.0818 (equivalent to P = 0.0014).