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. 2019 Jun 11;9:8470. doi: 10.1038/s41598-019-44878-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fgf8b reprograms proliferating preadipocytes. (A) White adipocytes were treated with Ffgf8b (125 ng/ml) for 48 hours either during proliferation, induction, early or late differentiation and compared to treatment during the entire differentiation. Black squares indicate days of Fgf8b treatment. Treatment during the entire differentiation period led to strongest Ucp1 induction. During proliferation and early differentiation cells were most susceptible for Fgf8b treatment, while inclusion of the induction phase into the treatment abrogated its effect. Bars are mean values ± SD, n = 5. (B) Time course of indicated mRNA expression following a 48 hours Fgf8b treatment pulse on proliferating preadipocytes. Points are mean values ± SD, n = 3.