Table 2.
Estimates of the effect of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine--oxoglutarate transaminase 3 (KAT3) proteins on type 2 diabetes (T2DM) using Mendelian Randomization with different methods.
| Outcome | Exposure (SD) |
SNPs | Method | OR | 95%CI | P value | Cochran’s Q statistic (p-value) | MR-Egger | |
|---|---|---|---|---|---|---|---|---|---|
| Intercept p value | I2 | ||||||||
| T2DM | IDO1 | 3a | IVW | 0.91 | 0.85, 0.97 | 0.003 | 0.86 (0.65) | 0.64 | 90.7% |
| MR-Egger | 0.87 | 0.70, 1.07 | 0.18 | ||||||
| WM | 0.91 | 0.85, 0.97 | 0.01 | ||||||
| 8 | IVW | 0.92 | 0.87, 0.97 | 0.002 | 2.75 (0.91) | 0.31 | 91.8% | ||
| MR-Egger | 0.87 | 0.76, 0.98 | 0.03 | ||||||
| WM | 0.92 | 0.86, 0.98 | 0.01 | ||||||
| MR-PRESSO | 0.92 | 0.89, 0.95 | <0.001 | ||||||
| KAT3 | 2b | IVW | 0.87 | 0.78, 0.96 | 0.01 | 1.11 (0.29) | |||
| 15 | IVW | 1.00 | 0.95, 1.05 | 0.97 | 13.42 (0.49) | 0.46 | 22.9% | ||
| MR-Egger | 0.97 | 0.88, 1.07 | 0.51 | ||||||
| WM | 1.03 | 0.96, 1.10 | 0.40 | ||||||
| MR-PRESSO | 1.00 | 0.95, 1.05 | 0.98 | ||||||
aNot enough instrumental variables for MR-PRESSO. bNot enough instrumental variables for MR-Egger, WM and MR-PRESSO.