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. 2019 Jun 5;7:217. doi: 10.3389/fped.2019.00217

Table 1.

Management of fever guidelines (from 29, modified).

Guidelines AAP SIP South- Africa NICE NSW SA WHO CANADA
Country USA Italy South Africa UK New Zealand South Australian Canada
Year 2011 2016 2013 2013 2010 2013 2013 2013
Age of target population Not specified 0–18 years Not specified <5 years 1 month−5 years <3 years <5 years Not-specified
SPECIFIC RECOMMENDATIONS
Combination of paracetamol/ibuprofen is not recommended Inline graphic(1) graphic file with name fped-07-00217-i0002.jpg graphic file with name fped-07-00217-i0002.jpg graphic file with name fped-07-00217-i0002.jpg nr graphic file with name fped-07-00217-i0002.jpg nr Inline graphic (3)
Alternating paracetamol/ibuprofen is not recommended Inline graphic (1) graphic file with name fped-07-00217-i0002.jpg graphic file with name fped-07-00217-i0002.jpg Inline graphic(2) graphic file with name fped-07-00217-i0002.jpg Inline graphic (2) nr Inline graphic (3)

Inline graphicAgree.

Inline graphicDisagree.

nr, not reported.

(1) Insufficient evidence to support or refute the routine use of combination treatment.

(2) Alternating the two drugs is possible if the discomfort persists or recurs using only one antipyretic.

(3) Do not alternate between using acetaminophen and ibuprofen as this can lead to dosing errors.