Table 3.

Comparison 1: combined therapy vs. single agent.

Outcome or subgroup	Studies	Participants	Statistical method	Effect estimate
Proportion remaining febrile	3		RR (M-H, Random, 95% CI)	Subtotals only
Hour 1	2	133	RR (M-H, Random, 95% CI)	0.46 [0.20, 1.07]
Hour 4	3	289	RR (M-H, Random, 95% CI)	0.18 [0.06, 0.53]
Hour 6	1	40	RR (M-H, Random, 95% CI)	0.10 [0.01, 0.71]
Mean temperature (°C)	4		MD (IV, Random, 95% CI)	Subtotals only
Hour 1	2	163	MD (IV, Random, 95% CI)	−0.29 [−0.45, −0.13]
Hour 4	3	713	MD (IV, Random, 95% CI)	−0.12 [−0.34, 0.10]
Hour 6	2	580	MD (IV, Random, 95% CI)	−0.04 [−0.13, 0.05]

RR, risk ratio; MD, mean difference.