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. 2019 Jun 5;10:537. doi: 10.3389/fphar.2019.00537

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Copyright © 2019 Li, Shan, Gao, Wang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of Lir on pressure overload induced cardiac hypertrophy. Mice were subjected to TAC surgery and treated with Lir for 25 days. Statistical results of the HW/BW, HW/TL, and LW/BW ratios (n = 10) at 4 weeks after TAC (A). The gross heart, HE staining (B) and CSA (n = 100 cells per section) (C) at 4 weeks after TAC. RT-PCR analysis of hypertrophic markers including ANP, BNP, and β-MHC from the heart of the different groups (n = 9) (D). Echocardiography results at 4 weeks after TAC (E, n = 10). Pressure loop measurements of systolic (SBP) and diastolic blood pressure (DBP) in different groups (n = 10 mice/group, F). ^∗P < 0.05, compared to the corresponding sham group; ^#P < 0.05, compared to the control-TAC group.