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. 2019 Jun 5;10:1218. doi: 10.3389/fmicb.2019.01218

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Copyright © 2019 Berni, Soscia, Djermoun, Ize and Bleves.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Working model: Tle3 targeting to the H2-T6SS machinery (left panel) Tle3 (in pink) is taken in charge in the cytoplasm by Tla3 (in orange) that binds VgrG2b (green). Upon Hcp2b (in dark grey) assembly into the growing sheath (light grey), the VgrG2b loaded with the Tle3 is placed at the tip of the Hcp arrow. Tle3 and VgrG2b_Cter delivery into bacteria (right panel). The sheath contraction in the cytoplasm propels the Hcp arrow towards the target bacterium. Tle3 associated with this expelled structure is thus translocated into target cells, as well as VgrG2b_Cter (green circle). The prey is killed (Prey^S) except if it has the Tli3 immunity (in blue) in the periplasm (Prey^R). The mechanism of resistance to VgrG2b_Cter is still unknown. OM, outer membrane; PG, peptidoglycan; IM, inner membrane; BP, base plate; MC, membrane complex. Prey^S, sensitive prey; Prey^R, resistant prey.