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. 2019 Jun 5;10:1262. doi: 10.3389/fimmu.2019.01262

Figure 2.

Figure 2

NK cells from patients with WHIM syndrome have similar intensity of CXCR4 cell surface expression but have significantly superior in vivo bone marrow homing compared to NK cells expanded from healthy donors. (A) Surface expression intensity of CXCR4 on expanded NK cells from patients with WHIM syndrome (white, n = 3 WHIM pts) vs. healthy donors (black, n = 9 donors). (B) Experiment schema illustrating injection of expanded human NK cells i.v. into NSG mice followed by a harvest 24 h later. (C) Proportion of CD56+ human NK cells in BM samples of mice injected with ex vivo expanded NK cells from healthy donors or from WHIM syndrome patients 24 h following infusion (one representative mouse from each group). (D) The fraction of human CD56+ cells recovered from the BM of mice injected with human NK cells (WHIM n = 15, healthy donors n = 9, data reported from 3 independent experiments; each experiment is represented by either white, gray or black circles). Statistical significance was evaluated by the Welch's T-test, two-tailed. Graphs present mean and error bars report SEM. *p < 0.05, ****p < 0.0001.