Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 5;10:1262. doi: 10.3389/fimmu.2019.01262

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Levy, Reger, Segerberg, Lambert, Leijonhufvud, Baumer, Carlsten and Childs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

NK cells transfected with CXCR4 coding mRNAs have no alterations in NK cell inhibitory and activating receptors and have preserved anti-tumor cytotoxic function. (A) Inhibitory and activation NK cell receptor expression 24 h post-transfection with CXCR4-coding mRNAs compared to non-transfected control NK cells (n = 6 donors, 1 experiment). (B–D) NK cell intracellular TNF-α and IFN-γ, and surface CD107a expression following a 4-h co-culture with K562 cells (n = 6 donors, 1 experiment). (E) NK cell degranulation measured by NK cell surface upregulation of CD107a in response to co-culture with various tumor cell lines (n = 4 donors, 4 independent experiments). Statistical significance was determined with the Student's paired t-test, two-tailed. Graphs present mean and error bars report SEM.