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. 2019 Jun 11;9:8512. doi: 10.1038/s41598-019-44739-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GQ1b decreases tau phosphorylation accompanied by increased levels of phospho-GSK3β in 3xTg-AD mice. (A) Western blotting and (B) its quantification revealed that GQ1b administration into the hippocampus of 3xTg-AD mice significantly reduced phospho-tau (T181, T205, T231) levels compared to aCSF-infused 3xTg-AD mice. (C) Western blotting and (D) its quantification showed that GQ1b infusion rescued the decrease in phospho-GSK3β levels without affecting expression of a representative tau phosphatase, PP2A. Western blotting band intensity was quantified by densitometry analysis on pTau, Tau, pGSK3β, GSK3β, PP2A, and GAPDH bands. Western blots shown represent typical results from three independent experiments, and the graphs show data from three independent experiments and are expressed as mean values ± SD. *p < 0.05, **p < 0.01 vs. WT + aCSF group, ^#p < 0.05, ^##p < 0.01 vs. AD + aCSF group.