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. 2019 Jun 7;12:4489–4498. doi: 10.2147/OTT.S202875

Table 3.

Clinical and biochemical toxicities

Author Year Clinical toxicities, N (%) Biochemical Toxicities, N (%) Severity, N (%)
Fatigue Anorexia Abdominal pain Nausea Vomiting Ascites Gastroduodenal ulceration Abumin Bilirubin Alkaline phosphatase Grade III–IVa
Saxena et al26 2010 16 (64.0) 4 (16.0) 10 (40.0) 4 (16.0) 2 (8.0) 4 (16.0) 1 (4.0) 1 (4.0) 1 (4.0) 1 (4.0) 4 (16.0)
Mosconi et al25 2016 2 (8.7) N/A 5 (21.7) N/A N/A 5 (21.7) N/A N/A 1 (4.3) N/A 2 (8.6)
Rafi et al24 2013 4 (21.0) N/A 6 (32.0) N/A N/A N/A 0 N/A 3 (15.8) N/A 2 (11.0)
Mouli et al23 2013 25 (54.0) 2 (4.0) 13 (28.0) 6 (13.0) 4 (9.0) 7 (15.0) 1 (2.0) 4 (9.0) 3 (7.0) 0 8 (18.0)
Hoffmann et al22 2012 N/A N/A 28 (85.0) 20 (61.0) 9 (27.0) N/A N/A N/A 23 (70.0) N/A N/A
Jia et al21 2017 21 (87.5) 19 (79.2) 10 (58.3) 15 (62.5) 4 (16.7) N/A 1 (4.2) 0 0 0 6 (25.0)
Soydal et al20 2016 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Swinburne et al19 2017 2 (6.7) N/A N/A N/A N/A N/A N/A N/A 4 (13.3) 1 (3.3) 0
Reimer et al18 2018 0 0 0 0 0 0 1 (5.0) 0 0 0 1 (5.0)
Orwat et al17 2017 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Paprottka et al16 2017 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Gangi et al13 2018 36 (42.3) N/A 16 (18.8) N/A N/A 5 (5.9) N/A N/A N/A 39 (46.0) 6 (7.0)
Filippi et al11 2015 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1 (4.0)
Beuzit et al12 2016 N/A N/A N/A N/A N/A 1 (2.0) N/A N/A N/A N/A 1 (2.0)
Shaker et al14 2018 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Camacho et al15 2014 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Note: aGrade III–IV toxicities including gastroduodenal ulceration.

Abbreviation: N/A, not available.