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. 2019 Jun 7;12:4403–4413. doi: 10.2147/OTT.S209907

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© 2019 Shi et al.

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The effect of NCTD on BCSLCs in vitro. (A) The protein expression of Cdc6-C in BCSLCs after NCTD treatment for 48 hr (0 μM, 50 μM, 100 μM and 200 μM) was detected by Western blotting. (B) The relative OD for Cdc6-C was determined from the Western blot band. (C) The expression of ATR-C, pChk1, pCdc25C in BCSLCs and UMUC3 cells after treatment with or without NCTD (50 μM) was detected by Western blotting. (D–F) The relative OD data for ATR-C, pChk1, pCdc25C was determined from the Western blot band. (G) Relative cell viability of different groups is shown. (*P<0.05).

Abbreviations: BCSLCs, bladder cancer stem-like cells; Cdc6-C, chromatin-binding Cdc6; NCTD, norcantharidin; ATR-C, Chromatin-binding ATR; pChk1, phosphorylated check point kinase 1; pCdc25C, phosphorylated Cdc25C.