Fig. 1.

IPGTT and OGTT revealed lower insulin levels in VE-PDPK1-KO mice, and an isolated islet perifusion study revealed a deterioration in GSIS in knockout mice. (a, b) Blood glucose levels (a) and serum insulin levels (b) during an IPGTT (n=7 mice). (c) Islet perifusion experiment; n=5 (control flox mice) or n=4 (VE-PDPK1-KO mice). (d–g) Blood glucose, insulin, active GLP-1 and glucagon levels during an OGTT; n=7 (control flox mice) or n=8 (VE-PDPK1-KO mice) (h, i) IPGTT conducted after 100 ng Ex-4 pre-treatment; n=7 (control flox mice) or n=8 (VE-PDPK1-KO mice). Black circles, VE-PDPK1-KO mice; white circles, control flox mice. Values are means ± SEM. *p<0.05 vs control flox mice