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. 2019 Jun 5;7:408. doi: 10.3389/fchem.2019.00408

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Copyright © 2019 Chen, Zhang, Zou and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustration of tumor targeting HACE modified DOX/PLGA microsphere fabrication and treatment process as TACE reagent. (B) DOX/HACE MS (HACE modified DOX/PLGA microsphere) treatment could significantly decrease tumor size in McA-RH7777 tumor-implanted rat model, in comparison with control or DOX MS (DOX/PLGA microsphere) treatments. The tumor was recorded by magnetic resonance imaging. Scale bar is 1 cm. [Reproduced with permission from Lee et al. (2018), Copyright 2018 Taylor & Francis].