Table 1.
Histological Grading of Oral Epithelial Dysplasia (Smith and Pindborg, 1969)
| Type of change | Severity of dysplasia | |||
|---|---|---|---|---|
| 1 | Drop-shaped retepegs | None (0) | Slight (2) | Marked (4) |
| 2 | Irregular epithelial stratification | None (0) | Slight (2) | Marked (5) |
| 3 | Keratinization of cells below keratinised layer | None (0) | Slight (1) | Marked (3) |
| 4 | Basal cell hyperplasia | None (0) | Slight (1) | Marked (4) |
| 5 | Loss of intercellular adherence | None (0) | Slight (1) | Marked (5) |
| 6 | Loss of polarity | None (0) | Slight (2) | Marked (6) |
| 7 | Hyperchromatic nuclei | None (0) | Slight (2) | Marked (5) |
| 8 | Increased nucleo-cytoplasmic ratio in basal and prickle cell layers | None (0) | Slight (2) | Marked (6) |
| 9 | Anisocytosis and anisonucleosis | None (0) | Slight (2) | Marked (6) |
| 10 | Pleomorphic cells and nuclei | None (0) | Slight (2) | Marked (6) |
| 11 | Mitotic activity | None (0) | Slight (1) | Marked (5) |
| 12 | Level of mitotic activity | None (0) | Slight (3) | Marked (10) |
| 13 | Presence of bizarre mitoses | None (0) | Slight (6) | Marked (10) |