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. 2019 Apr 9;46(3):241–250. doi: 10.1007/s10928-019-09632-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Mixture VPCs for linear PK data: upper panel displays MIXEST based VPCs while lower panel displays IP_mix based VPCs. One-compartment mixture model with 70/30% mixture proportions having fourfolds CL difference. (SUBPOP subpopulation number, P_mix estimated population proportion, ORIGID, SIMID individuals (%) allocated to respective subpopulations in original and simulated data respectively)