Table 1. Clinical trials of mesenchymal stromal cells in ARDS.
Clinicaltrials.gov | Country | Cell type | Placebo | Dose | Delivery | Follow-up | Patients |
---|---|---|---|---|---|---|---|
Published clinical trials | |||||||
NCT01902082 | China | AD-MSC | Saline | 106/kg | IV | 7 days | 12 (6/6) |
NCT01775774 | USA | BM-MSC | No | 1, 5, 10×106/kg | IV | 12 months | 9 (3/3/3) |
NCT02097641 | USA | BM-MSC | Plasmalyte | 107/kg | IV | 12 months | 60 (40/20) |
Ongoing clinical trials | |||||||
NCT02444455 | China | UC-MSC | No | 5×105/kg/day (3 days) | IV | 14 days | 20 |
NCT02112500 | Korea | BM-MSC | No | Not reported | IV | 28 days | 10 |
NCT02215811 | Sweden | BM-MSC | No | Not reported | Not reported | 12 months | 10 |
NCT02095444 | China | MB-MSC | No | 107/kg/week (2 weeks) | IV | 14 days | 20 |
NCT02611609 | UK | Multistem® | Saline | Not reported | Not reported | 12 months | 36 (12/12/12) |
NCT03042143 | UK | UC-CD362 MSC | Plasmalyte | 1, 2, 4×108 cells | IV | 14 days | 75 |
NCT02804945 | USA | BM-MSC | Plasmalyte | 3×106 cell/kg | IV | 60 days | 50 |
NCT03608592 | China | UC-MSC | Saline | 60×106 cells | IV | 28 days | 12 |
NCT03818854 | USA | BM-MSC | Cell reconstitution media | 107 cells/kg | IV | 60 days | 120 |
Mesenchymal stromal cell (MSC) clinical trials in ARDS patients. ARDS, acute respiratory distress syndrome; AD, adipose-derived; BM, bone marrow-derived; UC, umbilical cord-derived; MB, menstrual blood-derived; IV, intravenous.