Table 4. Main effects and PRS interactions with sex, age, and family history of alcohol use disorders for alcohol dependence, AUD symptom count, alcohol use, maximum drinks, and SRE-T.

Beta (SE), and p-value are reported.

	DSM-IV Alcohol Dependence (DSM4AD: PRS pT < 0.01)	DSM-5 AUD Symptom Count (DSM5AUDSX: PRS pT < 0.5)	Alcohol Use (PRS pT < 0.2)	Maximum Drinks (MAXD: PRS pT < 0.1)	Self-rating of effects of ethanol (SRE-T: PRS pT < 0.1)	Reduction/Cessation of problem drinking$ (Reduction: PRS pT < 0.1)
Sex	−0.986 (0.069), p < 2e-16	−1.569 (0.082), p < 2e-16	−1.029 (0.120), p<2e-16	−0.702 (0.020), p<2e-16	−0.490 (0.018), p<2e-16	−0.241 (0.014), p<2e-16
Sex*PRS	−0.015 (0.069), p = 0.833	0.149 (0.080), p = 0.064	0.099 (0.125), p = 0.428	0.032 (0.020), p = 0.103	0.021 (0.016), p = 0.185	0.008 (0.012), p = 0.485
Age	0.035 (0.007), p = 3.79e-07	0.025 (0.009), p = 0.003	0.020 (0.011), p = 0.084	0.002 (0.002), p = 0.258	−0.002 (0.002), p = 0.401	0.002 (0.002), p = 0.131
Age*PRS	−0.006 (0.007), p = 0.371	−0.003 (0.008), p = 0.753	0.005 (0.011), p = 0.670	7.28e-04 (0.002), p = 0.710	8.19e-4 (0.002), p = 0.601	−0.001 (0.001), p = 0.242
Family history	0.505 (0.084), p = 1.57e-09	0.666 (0.099), p = 1.96e-11	0.127 (0.126), p = 0.314	0.133 (0.024), p = 4.09e-08	0.080 (0.021), p = 1.69e-4	0.086 (0.017), p = 2.54e-07
Family history*PRS	−0.040 (0.082), p = 0.630	0.102 (0.095), p = 0.280	0.123 (0.130), p = 0.344	0.009 (0.023), p = 0.708	0.017 (0.020), p = 0.385	−0.004 (0.016), p = 0.812

^$as in Table 3, reported ∆R² is for the comparison between those with no lifetime AUD vs. those with lifetime AUD and current symptoms or no symptoms but high-risk drinking