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. 2019 May 31;5(1):e000942. doi: 10.1136/rmdopen-2019-000942

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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SIR data for all CZP-treated patients (RCT+OLE) for each malignancy type, standardised to the general population by age and gender (GLOBOCAN and SEER). (A) All malignancies excluding NMSC (GLOBOCAN data). (B) Lymphatic and haematopoietic malignancies (GLOBOCAN data). (C) All malignancies excluding NMSC (SEER data). *There were no lymphatic or haematopoietic malignancies in the axSpA subpopulation. Forest plots show SIRs with 95% CIs. PY calculated using total years of CZP exposure from the first dose of CZP to end of AE exposure period (if no malignancy) or to first malignancy. AE, adverse event; axSpA, axial spondyloarthritis; CD, Crohn’s disease; CZP, certolizumab pegol; NA, not applicable; NMSC, non-melanoma skin cancer; OLE, open-label extensions; PsA, psoriatic arthritis; PSO, psoriasis; PY: patient-years; RA, rheumatoid arthritis; RCT, randomised controlled trials; SIR, standardised incidence ratio.