Table 3.

Stepwise Cox regression modeled analysis for associations between low Klotho levels and the occurrence of the primary endpoint (all-cause death or myocardial infarction or stroke)

	Klotho
	HR (95% CIs) For the low klotho group	P value
Model 1	2.137 (1.124–4.065)	0.021
Model 2	2.081 (1.093–3.960)	0.026
Model 3	2.089 (1.097–3.976)	0.025
Model 4	2.090 (1.096–3.984)	0.025
Model 5	2.476 (1.184–5.178)	0.016
Model 6	2.759 (1.223–6.224)	0.014

Model 1: Unadjusted; Model 2: Adjusted for cFGF-23; Model 3: Adjusted for cFGF-23 and iPTH; Model 4: Adjusted for cFGF-23, iPTH and Ca x P; Model 5: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension and smoking; Model 6: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension, smoking, cfPWV and ccIMT

Abbreviations: Ca x P Calcium x phosphorus product, ccIMT Common carotid Intima Media Thickness, CI Confidence intervals, HR Hazard ratio, cFGF-23 c-terminal Fibroblast Growth Factor 23, cfPWV Carotid - femoral Pulse Wave Velocity, iPTH Intact parathormone