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. 2019 Jun 11;11:89. doi: 10.1186/s13148-019-0679-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Bisulfite pyrosequencing analysis of candidate CpG loci in hiPSC-CMs: test of AVM pattern. The methylation values (percentage) of the initial discovery set (450K array analysis of atrial (n = 44, coloured dark blue) and ventricular (n = 5, coloured light blue) cardiac tissues from patients with CHDs) and in vitro-cultivated atrial and ventricular subtypes of hiPSC-CM 2D monolayers and 3D-engineered heart tissues (bisulfite pyrosequencing analysis, n = 4 atrial-like and n = 8 ventricular-like hiPSC-CMs; coloured dark violet and magenta, respectively) are depicted. CpG loci with significant (p < 0.05) differences in atrial and ventricular-like hiPSC-CMs showing similar AVM pattern as compared to the pattern in primary human atrial and ventricular cardiac tissues (discovery set) are marked with ‘AVM’. ‘Tendency loci’ with similar AVM pattern, that did not reach significance, are marked with ‘AVM*’ and loci showing opposite AVM pattern are marked with ‘inv’. Data is presented as standard box-and-whiskers plots (whiskers, 5th—95th percentile)