. 2019 Jun 11;4:2. doi: 10.1186/s41199-019-0041-4

Table 3.

Pharmacologic and lifestyle interventions

Study	Settings/Patients	Study Design/Intervention	Timing of intervention	Assessment timepoints	Measures	Results	Methodological Quality
Lydiatt et al. (2013) [24]	148 HNC pts.; Nebraska	RCT. Intervention group received escitalopram pharmacotherapy for 16 weeks vs. placebo pill through their oncology team.	before treatment started	baseline, 2, 4, 6, 8, 10, 12, 16, 20, 24, and 28 weeks	QIDS, MINI, QIDS-C, WQ-QOL, FIBSER (Frequency, Intensity, and Burden of Side Effects Rating)	Prophylactic escitalopram reduced depression rates and improved QOL. Radiation group had highest rates of depression.	6
Capozzi et al. (2016) [25]	60 HNC pts.; Canada	RCT. Intervention group received a lifestyle intervention (physician referral, health education for 6 sessions, behavior change support, individualized exercise program with resistance training, and group exercise setting 2x weekly). Control group was a delayed group of the same intervention.	new diagnosis - randomized between immediate lifestyle intervention vs. 12 week delayed	baseline, 12, 24, 36, 48 weeks	physical activity, BMI, lean body mass and percentage body fat; QOL: FACT-HN; Depression: CES-D, Nutrition - patient generated subjective global assessment	Delayed group were more able to complete intervention. No difference in body composition between groups. Potential benefit regardless of timing. No diff in QOL or depression - both declined at 12 weeks then improved at 24 weeks.	5

Study

Settings/Patients

Study Design/Intervention

Timing of intervention

Assessment timepoints

Measures

Results

Methodological Quality

Lydiatt et al. (2013) [24]

148 HNC pts.; Nebraska

RCT. Intervention group received escitalopram pharmacotherapy for 16 weeks vs. placebo pill through their oncology team.

before treatment started

baseline, 2, 4, 6, 8, 10, 12, 16, 20, 24, and 28 weeks

QIDS, MINI, QIDS-C, WQ-QOL, FIBSER (Frequency, Intensity, and Burden of Side Effects Rating)

Prophylactic escitalopram reduced depression rates and improved QOL. Radiation group had highest rates of depression.

Capozzi et al. (2016) [25]

60 HNC pts.;

Canada

RCT. Intervention group received a lifestyle intervention (physician referral, health education for 6 sessions, behavior change support, individualized exercise program with resistance training, and group exercise setting 2x weekly). Control group was a delayed group of the same intervention.

new diagnosis - randomized between immediate lifestyle intervention vs. 12 week delayed

baseline, 12, 24, 36, 48 weeks

physical activity, BMI, lean body mass and percentage body fat; QOL: FACT-HN; Depression: CES-D, Nutrition - patient generated subjective global assessment

Delayed group were more able to complete intervention. No difference in body composition between groups. Potential benefit regardless of timing. No diff in QOL or depression - both declined at 12 weeks then improved at 24 weeks.